GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2243480 | 1 | rs6949812 | chr7:65387101 | RABGEF1 | chr7:66093890-66276446:+ | 0.54 | 6.71 | 5.64E-11 | Diabetic kidney disease |
| THCA | cis | rs1451375 | 1 | rs6949897 | chr7:50621920 | FIGNL1 | chr7:50511834-50518088:- | -0.16 | -4.33 | 1.79E-5 | Malaria |
| THCA | cis | rs568617 | 1 | rs694994 | chr11:65653309 | CTSW | chr11:65647284-65651212:+ | -0.6 | -15.78 | 1.87E-45 | Crohn's disease |
| THCA | cis | rs568617 | 1 | rs694994 | chr11:65653309 | SNX32 | chr11:65601410-65621170:+ | 0.61 | 9.22 | 9.4E-19 | Crohn's disease |
| THCA | cis | rs2157926 | 1 | rs6951067 | chr7:87288324 | DBF4 | chr7:87505544-87538856:+ | -0.26 | -3.93 | 9.57E-5 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs6951245 | 1 | rs6951245 | chr7:1058193 | ZFAND2A | chr7:1192544-1199855:- | -0.25 | -3.73 | 0.000215 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| THCA | cis | rs10232172 | 1 | rs6951801 | chr7:54174070 | SEC61G | chr7:54819941-54826939:- | -0.22 | -3.38 | 0.000785 | Periodontal disease-related phenotypes |
| THCA | cis | rs6952407 | 1 | rs6952407 | chr7:66045512 | GUSB | chr7:65425675-65447246:- | -0.35 | -7.08 | 5.1E-12 | Cotinine glucuronidation |
| THCA | cis | rs6952407 | 1 | rs6952407 | chr7:66045512 | LOC493754 | chr7:65993446-66057363:- | 0.19 | 3.38 | 0.000778 | Cotinine glucuronidation |
| THCA | cis | rs6952407 | 1 | rs6952407 | chr7:66045512 | RABGEF1 | chr7:66093890-66276446:+ | -0.51 | -10.33 | 1.04E-22 | Cotinine glucuronidation |
| THCA | cis | rs6952407 | 1 | rs6952407 | chr7:66045512 | TYW1 | chr7:66461817-66704496:+ | -0.18 | -3.96 | 8.68E-5 | Cotinine glucuronidation |
| THCA | cis | rs2157926 | 1 | rs6952943 | chr7:87505653 | DBF4 | chr7:87505544-87538856:+ | -0.27 | -3.74 | 0.000203 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs858249 | 1 | rs6955117 | chr7:23234140 | NUPL2 | chr7:23221446-23240629:+ | -0.39 | -5.44 | 8.44E-8 | Chronic obstructive pulmonary disease |
| THCA | cis | rs858249 | 1 | rs6955934 | chr7:23251499 | NUPL2 | chr7:23221446-23240629:+ | -0.43 | -5.76 | 1.49E-8 | Chronic obstructive pulmonary disease |
| THCA | cis | rs875971 | 1 | rs6956179 | chr7:65806659 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.26 | 2.51E-5 | Aortic root size |